The Synthetic Organic Chemist’s Companion

Diversity-oriented synthesis; a challenge for synthetic chemists.

The efficient, simultaneous synthesis of structurally diverse compounds, better known as diversity-oriented synthesis (DOS), is not obvious, and remains a challenge to synthetic chemistry. This personal account details why DOS has such enormous implications for the discovery of small molecules with desired properties, such as catalysts, synthetic reagents, biological probes and new drugs, Also,...

Development of Sustainable Biocatalytic Reduction Processes for Organic Chemists

Among the different factors contributing to a good chemical manufacturing process, the process efficiency and specifically volume–time output in terms of reactor capacity and cycle time, respectively, have been given the largest weight – among the conversion costs, with material cost being the second [1]. Raw materials or intermediates with a higher oxidation state than the target products are ...

Synthetic Organic Chemistry

Synthetic biology: lessons from the history of synthetic organic chemistry.

The mid-nineteenth century saw the development of a radical new direction in chemistry: instead of simply analyzing existing molecules, chemists began to synthesize them--including molecules that did not exist in nature. The combination of this new synthetic approach with more traditional analytical approaches revolutionized chemistry, leading to a deep understanding of the fundamental principl...

The Chemists' War on Disease

For nearly a century and a half scientists have been studying ways of immunizing people against various diseases by artificial methods. Working mostly by trial and error they have devised reasonably safe vaccines and antisera for many diseases with a resulting spectacular decrease in mortality. T h e usual proceedure for vaccination is to inject the patient with the diseases-producing organisms...